Unusual Hyperchromatic Crowded Groups in a Papanicolaou Test
Andre L. Moreira, MD, PhD and Rusmir Feratovic, MHA, CT (ASCP)
Presentation Date: December 2011; Expires: December 2014
A 26 year old female presented at Memorial Sloan-Kettering Cancer Center (MSKCC) with a history of an umbilical hernia. The hernia was repaired at an outside facility and the biopsy was benign. Several months later, however, she began to notice some swelling and pain in the umbilical area. PET/CT scans were done and revealed two foci with abnormal metabolic activity in the pelvis. A partially calcified mass was observed on the left side of the pelvis that had an SUV of 3.7; and a larger mass near the rectum had an SUV of 8.7. Physical exam revealed no masses or lesions in the vulva, vagina, or cervix. However, a 5-6 cm firm fixed mass was appreciated when the uterus and rectum were examined. A cervical-vaginal cytology specimen and endometrial biopsies were obtained. The cervical-vaginal specimen was collected in PreservCyt® and sent to the cytology service laboratory. An endometrial biopsy was also obtained in the same procedure. One ThinPrep® slide was prepared form the cytology specimen and stained with the Papanicolaou stain. The surgical specimen was paraffin embedded and stained with hematoxylin and eosin.