Molecular Diagnostics in Thyroid FNA Samples
Marina N. Nikiforova, MD
Presentation date: December 11, 2012; Expires: December 11, 2015
Fine needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate clinical management. Somatic mutations and other molecular alterations have been recognized as helpful diagnostic and prognostic markers for thyroid cancer. Molecular testing for BRAF, RAS, RET/PTC, and PAX8/PPARy mutations is feasible in clinical FNA samples, helps to improve the diagnostic accuracy of FNA cytology, and offers a valuable tool for management of patients with thyroid nodules.